Brand from Japan: Kose. A medicated wrinkle-improving serum that works deeply on wrinkles around the eyes and mouth.Wrinkle improvement care that will change the future with a double approach to the dermis and epidermis.A medicated wrinkle-improving serum that works deeply on wrinkles around the eyes and mouth.How to use:Please use at the end of morning and evening care.If you are using cream, please use this product after that.Apply an appropriate amount to areas where wrinkles are a concern, such as the eyes and mouth.One eye is a guide for one rice grain.