Brand from United States: Skin Ceuticals. Backed by more than 15 years of glycation research and expertise, A.G.E. Interrupter Advanced is a potent anti-wrinkle cream that helps correct and defend against visible signs of aging, including wrinkling, laxity, and dullness. Formulated with 18% concentrated ProxylaneTM, 4.25% wild fruit flavonoids and 0.1% glycyrrhetinic acid, this breakthrough anti-wrinkle face cream is clinically proven to visibly smooth fine lines and five types of wrinkles impacted by glycation and collagen decline. A.G.E. Interrupter Advanced is physician-tested to complement professional collagen-remodeling treatments, like RF microneedling.How to use:Twice daily, massage a thin, even layer of A.G.E. Interrupter Advanced wrinkle cream onto the entire face, neck, and chest.If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.